DNA Binding Motif

						

			
Accessions: THRB_7 (HT-SELEX2 May2017), MA1575.1 (JASPAR 2024)

			
Names: THRB, THRB(var.2)
Organisms: Homo sapiens
Libraries: HT-SELEX2 May2017 1, JASPAR 2024 2
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: HT-SELEX
Length: 19
Consensus: gTGwCCTyrhyrAGGwCAc
Weblogo: 
PSSM: P0      A      C      G      T
01   1010    624   1640    837      g
02     26    618     15   4111      T
03    252    642   4111    230      G
04   4111    351    432   1787      w
05     29   4111      2      0      C
06      1   4111      2      8      C
07      0   1178     77   4111      T
08    286   1512    872   1441      y
09   2454    241   1353     63      r
10   1060   1033    939   1079      h
11     63   1266    312   2470      y
12   1469    904   1488    251      r
13   4111    106   1233      2      A
14      0      3   4111      0      G
15      0      0   4111     30      G
16   1688    470    303   4111      w
17    199   4111    686    291      C
18   4111      5    629      5      A
19    835   1649    610   1017      c
Type: Heterodimer
Binding TFs: P10828 (Ligand-binding domain of nuclear hormone receptor, Zinc finger, C4 type (two domains))
THRB (Zinc finger, C4 type (two domains))
P10828
			
Publications: Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]


Lu C, Cheng SY. Thyroid hormone receptors regulate adipogenesis and carcinogenesis via crosstalk signaling with peroxisome proliferator-activated receptors. J Mol Endocrinol 44:143-54 (2010). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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