DNA Binding Motif

						

			
Accessions: 5mhk_AB (3D-footprint 20231221)

			
Names: RS1
Organisms: Human herpes simplex virus 1, Human herpesvirus 1 (strain 17) (HHV-1)
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: ICP4 DNA-binding domain in complex with 19mer DNA duplex from its own promoter
Length: 8
Consensus: CknATCGy
Weblogo: 
PSSM: P0      A      C      G      T
01     16     72      8      0      C
02      8     16     48     24      k
03     24     24     24     24      n
04     96      0      0      0      A
05      0      0      0     96      T
06      0     96      0      0      C
07      0      0     96      0      G
08      8     24      8     56      y
Type: Heterodimer
Binding TFs: 5mhk_A (Herpesvirus ICP4-like protein N-terminal region)
5mhk_B (Herpesvirus ICP4-like protein N-terminal region)
Binding Sites: 5mhk_E
5mhk_F
			
Publications: Tunnicliffe RB, Lockhart-Cairns MP, Levy C, Mould AP, Jowitt TA, Sito H, Baldock C, Sandri-Goldin RM, Golovanov AP. The herpes viral transcription factor ICP4 forms a novel DNA recognition complex. Nucleic Acids Res 45:8064-8078 (2017). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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