DNA Binding Motif

						

			
Accessions: NEUROG2_full (HumanTF 1.0), MA0669.1 (JASPAR 2024)

			
Names: NEUROG2
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: dimeric; SELEX cycle: 4, HT-SELEX
Length: 10
Consensus: raCATATGtY
Weblogo: 
PSSM: P0      A      C      G      T
01    246      2    180      0      r
02    426    150     65      0      a
03      1    426      0      5      C
04    426      0      3      0      A
05      4      5     20    426      T
06    426      8      5      0      A
07      5      3      0    426      T
08      0      0    426      0      G
09      3    170    147    426      t
10      0    307      0    119      Y
Type: Heterodimer
Binding TFs: NEUROG2_full (Helix-loop-helix DNA-binding domain)
Q9H2A3 (Helix-loop-helix DNA-binding domain)
Q9H2A3
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Henke RM, Meredith DM, Borromeo MD, Savage TK, Johnson JE. Ascl1 and Neurog2 form novel complexes and regulate Delta-like3 (Dll3) expression in the neural tube. Dev Biol 328:529-40 (2009). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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