DNA Binding Motif

						

			
Accessions: 5cbz_AB (3D-footprint 20231221)

			
Names: AncMR DNA Binding Domain
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: AncMR DNA Binding Domain - (+)GRE Complex
Length: 13
Consensus: GnnCAnnnTGtnC
Weblogo: 
PSSM: P0      A      C      G      T
01     10      0     86      0      G
02     24     24     24     24      n
03     24     24     24     24      n
04      0     96      0      0      C
05     96      0      0      0      A
06     24     24     24     24      n
07     24     24     24     24      n
08     24     24     24     24      n
09     10     10     10     66      T
10      0      0     96      0      G
11     10     10     12     64      t
12     24     24     24     24      n
13      0     85      0     11      C
Type: Heterodimer
Binding TFs: 5cbz_A (Zinc finger, C4 type (two domains))
5cbz_B (Zinc finger, C4 type (two domains))
Binding Sites: 5cbz_C
5cbz_D
			
Publications: Hudson WH, Kossmann BR, de Vera IM, Chuo SW, Weikum ER, Eick GN, Thornton JW, Ivanov IN, Kojetin DJ, Ortlund EA. Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space. Proc Natl Acad Sci U S A 113:326-31 (2016). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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