DNA Binding Motif

						

			
Accessions: SP1_2 (HT-SELEX2 May2017), MA0079.4 (JASPAR 2024)

			
Names: SP1
Organisms: Homo sapiens, Rattus norvegicus
Libraries: HT-SELEX2 May2017 1, JASPAR 2024 2
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: HT-SELEX
Length: 15
Consensus: ywrRCCACGCCCmCh
Weblogo: 
PSSM: P0      A      C      G      T
01   7866  13273   9691  18833      y
02  28233   1872    999  19877      w
03  28895   1530  19477   1184      r
04  14584      0  37543    153      R
05    962  48854     82    124      C
06     55  49649      0   1670      C
07  42154  12672      0      0      A
08      0  49660      0     31      C
09    959      0  48957    867      G
10      0  49666      0     17      C
11      8  49662      0      0      C
12      0  48772      0   1440      C
13  24666  24196     15   1373      m
14   1195  37612    919  10717      C
15  12598  15606   3044  18415      h
Type: Heterodimer
Binding TFs: P08047 (Zinc finger, C2H2 type, Zinc-finger double domain, C2H2-type zinc finger)
SP1 (Zinc finger, C2H2 type, Zinc-finger double domain, C2H2-type zinc finger)
P08047
			
Publications: Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]


Raiber EA, Kranaster R, Lam E, Nikan M, Balasubramanian S. A non-canonical DNA structure is a binding motif for the transcription factor SP1 in vitro. Nucleic Acids Res 40:1499-508 (2012). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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