DNA Binding Motif

						

			
Accessions: CLOCK_DBD (HumanTF 1.0), MA0819.1 (JASPAR 2024)

			
Names: CLOCK
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: dimeric; SELEX cycle: 3, HT-SELEX
Length: 10
Consensus: aACACGTGty
Weblogo: 
PSSM: P0      A      C      G      T
01    226     35     93     75      a
02    429     85     89     13      A
03     11    429      2      2      C
04    429      5     15      0      A
05     16    429      0     28      C
06     40      0    429      0      G
07      3      5      5    429      T
08      0      3    429      9      G
09      1    152    110    429      t
10     89    128     39    174      y
Type: Heterodimer
Binding TFs: CLOCK_DBD (Helix-loop-helix DNA-binding domain)
O15516 (Helix-loop-helix DNA-binding domain, PAS fold, PAS fold)
O15516
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Yoshitane H, Ozaki H, Terajima H, Du NH, Suzuki Y, Fujimori T, Kosaka N, Shimba S, Sugano S, Takagi T, Iwasaki W, Fukada Y. CLOCK-controlled polyphonic regulation of circadian rhythms through canonical and noncanonical E-boxes. Mol Cell Biol 34:1776-87 (2014). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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