DNA Binding Motif

						

			
Accessions: 3tq6_AB (3D-footprint 20231221)

			
Names: Transcription factor A, mitochondrial
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Crystal structure of human mitochondrial transcription factor A, TFAM or mtTFA, bound to the light strand promoter LSP
Length: 37
Consensus: ACAGnnAnnnnCCAACAnnnaACAGTCAnnnnCCAAC
Weblogo: 
PSSM: P0      A      C      G      T
01     94      0      2      0      A
02      0     96      0      0      C
03     96      0      0      0      A
04      0      0     96      0      G
05     24     24     24     24      n
06     24     24     24     24      n
07     84      5      2      5      A
08     24     24     24     24      n
09     24     24     24     24      n
10     24     24     24     24      n
11     24     24     24     24      n
12      0     96      0      0      C
13      0     96      0      0      C
14     96      0      0      0      A
15     96      0      0      0      A
16      0     93      2      1      C
17     82      5      2      7      A
18     24     24     24     24      n
19     24     24     24     24      n
20     24     24     24     24      n
21     65     10      8     13      a
22     93      2      1      0      A
23      0     96      0      0      C
24     96      0      0      0      A
25      0      0     96      0      G
26      9      5      8     74      T
27      8     78      5      5      C
28     82      5      2      7      A
29     24     24     24     24      n
30     24     24     24     24      n
31     24     24     24     24      n
32     24     24     24     24      n
33      0     93      2      1      C
34      0     96      0      0      C
35     96      0      0      0      A
36     96      0      0      0      A
37      0     94      2      0      C
Type: Heterodimer
Binding TFs: 3tq6_A (HMG (high mobility group) box, Domain of unknown function (DUF1898))
3tq6_B (HMG (high mobility group) box, Domain of unknown function (DUF1898))
Binding Sites: 3tq6_C
3tq6_D
			
Publications: Rubio-Cosials A, Sidow J.F, Jiménez-Menéndez N, Fernández-Millán P, Montoya J, Jacobs H.T, Coll M, Bernadó P, Solà M. Human mitochondrial transcription factor A induces a U-turn structure in the light strand promoter. Nature structural & molecular biology 18:1281-9 (2011). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.