DNA Binding Motif

Accessions: UP00159A_1 (UniPROBE 20160601)
Names: Homeobox protein SIX2, Sine oculis homeobox homolog 2, sine oculis-related homeobox 2 homolog (Drosophila), Six2
Organisms: Mus musculus
Libraries: UniPROBE 20160601 1
1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed]
Length: 17
Consensus: rakrGGGTATCAcdwyt
Weblogo:
PSSM: P0 A C G T
01 0.45 0.10 0.29 0.16 r
02 0.59 0.12 0.09 0.21 a
03 0.19 0.04 0.26 0.51 k
04 0.30 0.11 0.52 0.07 r
05 0.12 0.04 0.80 0.04 G
06 0.01 0.03 0.92 0.04 G
07 0.13 0 0.87 0 G
08 0 0 0.05 0.95 T
09 0.96 0 0.04 0 A
10 0 0 0 0.99 T
11 0.01 0.98 0 0.01 C
12 0.90 0.02 0.05 0.02 A
13 0.17 0.51 0.08 0.25 c
14 0.25 0.17 0.29 0.29 d
15 0.34 0.08 0.06 0.52 w
16 0.23 0.27 0.22 0.28 y
17 0.17 0.08 0.22 0.52 t
Binding TFs: UP00159A (Homeobox domain, Homeobox KN domain)
Binding Sites: AATGATAC
ACGTATCA
AGGGTATC
AGGTATCA
AGTGATAC
ATGATACC
ATGATACG
ATGATATC
CGATACCC
CGGTATCA
GATACCCC
GATATCAC
GATATCCC
GATGATAC
GGATATCA
GGTATCAA
GGTATCAC
TGATACCA
TGATATCA
GGTGATAC
Publications: Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed]

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