DNA Binding Motif

						

			
Accessions: DRGX_2 (HT-SELEX2 May2017), MA1481.1 (JASPAR 2024)

			
Names: DRGX
Organisms: Homo sapiens
Libraries: HT-SELEX2 May2017 1, JASPAR 2024 2
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: HT-SELEX
Length: 8
Consensus: yyAATTAs
Weblogo: 
PSSM: P0      A      C      G      T
01   1172   8180   2692   6687      y
02   1079   5997   1111   8870      y
03  14867    501   2037      0      A
04  14867      0      0      0      A
05      0      0      0  14867      T
06      0    813    209  14867      T
07  14867     17    962    144      A
08   3117   4651   3995   3105      s
Type: Heterodimer
Binding TFs: DRGX (Homeobox domain)
A6NNA5 (Homeobox domain, OAR domain)
A6NNA5
			
Publications: Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]


Monteiro CB, Costa MF, Reguenga C, Lima D, Castro DS, Monteiro FA. Paired related homeobox protein-like 1 (Prrxl1) controls its own expression by a transcriptional autorepression mechanism. FEBS Lett 588:3475-82 (2014). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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