DNA Binding Motif

						

			
Accessions: TFAP2C_DLX3_2 (HumanTF2 1.0)

			
Names: TFAP2C_DLX3
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX
Length: 23
Consensus: gsCCysrRGscaygskrTAATkr
Weblogo: 
PSSM: P0      A      C      G      T
01    408    433    639    392      g
02    186    671   1201    129      s
03     22   1872    225     13      C
04      8   1872     17    533      C
05    111    517    392    852      y
06    257    546    644    425      s
07    914    308    573     77      r
08    530     72   1342      5      R
09     18      3   1872     14      G
10     99    727   1872    207      s
11    135   1872    617    472      c
12   1872    362    762    397      a
13    307    715    322    528      y
14    355    346    747    424      g
15    445    619    471    336      s
16    423    358    566    524      k
17    490    378    639    364      r
18    264    529     82   1872      T
19   1872    266    303     96      A
20   1872      6     37     82      A
21    141    206    227   1872      T
22    266    310    761   1111      k
23    817     94   1055    105      r
Type: Heterodimer
Binding TFs: DLX3_TF2 (Homeobox domain)
TFAP2C_TF1 (Transcription factor AP-2)
DLX3_Crystal (Homeobox domain)
DLX3_Full (Homeobox domain, Homeobox protein distal-less-like N terminal )
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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