DNA Binding Motif

						

			
Accessions: MGA_EVX1_1 (HumanTF2 1.0), MA1960.1 (JASPAR 2024)

			
Names: MGA_EVX1, MGA::EVX1
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 12
Consensus: rGGTGwTAATkw
Weblogo: 
PSSM: P0      A      C      G      T
01   2290    140   1471    615      r
02    607     73   2290    127      G
03     27     23   2290     74      G
04    104     45     25   2290      T
05      3     21   2290      0      G
06    833    159    219   1078      w
07     22     64     83   2290      T
08   2290      0      5     54      A
09   2290     69     74     95      A
10     90     41     19   2290      T
11     14    152   1393    897      k
12   1276    175    657   1014      w
Type: Heterodimer
Binding TFs: EVX1_TF1 / EVX1_TF2 (Homeobox domain)
MGA_TF1 (T-box)
Q8IWI9 (Helix-loop-helix DNA-binding domain, T-box)
Q8IWI9 (Helix-loop-helix DNA-binding domain, T-box)
Q8IWI9
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]


Guturu H, Doxey AC, Wenger AM, Bejerano G. Structure-aided prediction of mammalian transcription factor complexes in conserved non-coding elements. Philos Trans R Soc Lond B Biol Sci 368:20130029 (2013). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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