DNA Binding Motif

						

			
Accessions: DMRTA1_2 (HT-SELEX2 May2017), UN0115.1 (JASPAR 2024), MA1707.1 (JASPAR 2024)

			
Names: DMRTA1
Organisms: Homo sapiens
Libraries: HT-SELEX2 May2017 1, JASPAR 2024 2
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: HT-SELEX
Length: 12
Consensus: aattGwTACAwt
Weblogo: 
PSSM: P0      A      C      G      T
01   1860    434    582    811      a
02   1773    325    649    898      a
03   1096    644    409   2671      t
04    383    563    512   2671      t
05      0      5   2671      0      G
06   1076    761      1   1595      w
07    771     89      0   2671      T
08   2671      4     15      0      A
09      2   2671      0      0      C
10   2671      0     39    342      A
11   1392    299    587   2671      w
12    588    650    585   2671      t
Type: Heterodimer
Binding TFs: DMRTA1 / Q5VZB9 (DM DNA binding domain, DMRTA motif)
Q5VZB9
			
Publications: Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]


Murphy M. W., Zarkower D., Bardwell V. J. Vertebrate DM domain proteins bind similar DNA sequences and can heterodimerize on DNA.. BMC Mol. Biol. 8:58 (2007). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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