DNA Binding Motif

						

			
Accessions: ETV5_HOXA2_1 (HumanTF2 1.0), MA1948.1 (JASPAR 2024)

			
Names: ETV5_HOXA2, ETV5::HOXA2
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 14
Consensus: rsCGGAwGTmATTA
Weblogo: 
PSSM: P0      A      C      G      T
01    201     25    144     42      r
02     64    106    117     57      s
03     56    345     55     30      C
04      0      0    345      3      G
05     11      0    345      0      G
06    345      8      3     13      A
07    208     35     21    137      w
08     26     24    345      3      G
09      0     89      0    345      T
10    201    144     62     19      m
11    345     17     95      9      A
12      0     31      4    345      T
13      0     95     34    345      T
14    345     15      0     30      A
Type: Heterodimer
Binding TFs: P41161 (Ets-domain, PEA3 subfamily ETS-domain transcription factor N terminal domain)
ETV5_TF1 (Ets-domain)
HOXA2_TF2 (Homeobox domain)
P41161
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]


Guturu H, Doxey AC, Wenger AM, Bejerano G. Structure-aided prediction of mammalian transcription factor complexes in conserved non-coding elements. Philos Trans R Soc Lond B Biol Sci 368:20130029 (2013). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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