DNA Binding Motif

						

			
Accessions: ETV2_FIGLA_1 (HumanTF2 1.0), MA1941.1 (JASPAR 2024)

			
Names: ETV2_FIGLA, ETV2::FIGLA
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 16
Consensus: rsCGGAArCAGsTGgd
Weblogo: 
PSSM: P0      A      C      G      T
01   7245   1312   5267   2296      r
02   2429   8518   4342    832      s
03   2882  14178   1033    404      C
04    273    449  16064    222      G
05    308    212  16067    344      G
06  15973    604    522    593      A
07  14290    559    494   3629      A
08   9073   1959   4917    172      r
09    168  15983    414    688      C
10  16007    379    780    310      A
11    346   3705  15259    311      G
12    798   6725  12686    250      s
13    364    441    476  16024      T
14    385    241  16030    486      G
15   2049   3574   6655   3842      g
16   4089   2846   4266   4918      d
Type: Heterodimer
Binding TFs: FIGLA_TF2 (Helix-loop-helix DNA-binding domain)
ETV2_TF1 (Ets-domain)
Q6QHK4 (Helix-loop-helix DNA-binding domain)
Q6QHK4
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]


Ibarra IL, Hollmann NM, Klaus B, Augsten S, Velten B, Hennig J, Zaugg JB. Mechanistic insights into transcription factor cooperativity and its impact on protein-phenotype interactions. Nat Commun 11:124 (2020). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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