DNA Binding Motif

						

			
Accessions: RXRG_4 (HT-SELEX2 May2017), MA1556.1 (JASPAR 2024)

			
Names: RXRG, RXRG(var.2)
Organisms: Homo sapiens
Libraries: HT-SELEX2 May2017 1, JASPAR 2024 2
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: HT-SELEX
Length: 14
Consensus: rrGGTCAyGACCyy
Weblogo: 
PSSM: P0      A      C      G      T
01    803    164   1071     79      r
02   1264      7    853      0      r
03      0    107   2117      0      G
04      7     31   2117     99      G
05     12      5     33   2117      T
06      0   2117      1     16      C
07   2117     15      0      0      A
08      0    838      0   1279      y
09     64     55   2117     26      G
10   2117    214     78    119      A
11    144   2117     63     64      C
12    144   2117    176     37      C
13     23    882     57   1235      y
14    135    996    226    761      y
Type: Heterodimer
Binding TFs: P48443 / RXRG (Ligand-binding domain of nuclear hormone receptor, Zinc finger, C4 type (two domains), Nuclear/hormone receptor activator site AF-1)
P48443
			
Publications: Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]


Khan SA, Vanden Heuvel JP. Role of nuclear receptors in the regulation of gene expression by dietary fatty acids (review). J Nutr Biochem 14:554-67 (2003). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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