DNA Binding Motif

						

			
Accessions: PITX2_4 (HT-SELEX2 May2017), MA1547.1 (JASPAR 2024)

			
Names: PITX2
Organisms: Homo sapiens
Libraries: HT-SELEX2 May2017 1, JASPAR 2024 2
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: HT-SELEX
Length: 8
Consensus: hTAATCCc
Weblogo: 
PSSM: P0      A      C      G      T
01   6050   5519   4140   5436      h
02    259      0      0  10956      T
03  10956      0     17      0      A
04  10956      0      0      0      A
05      0      0    147  10956      T
06      0  10956      0   1455      C
07    197  10956    248    364      C
08   2119   5773   1692   1371      c
Type: Heterodimer
Binding TFs: Q99697 (Homeobox domain, OAR domain)
PITX2 (Homeobox domain)
Q99697
			
Publications: Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]


Amendt B. A., Sutherland L. B., Semina E. V., Russo A. F. The molecular basis of Rieger Syndrome. J. Biol. Chem. 273:20066-20072 (1998). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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