DNA Binding Motif

Accessions: 6wc5_N (3D-footprint 20231221)
Names: Homeobox protein Nkx-2.5
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Crystal Structure of a Ternary MEF2B/NKX2-5/myocardin enhancer DNA Complex
Length: 6
Consensus: CnCTTT
01 9 67 11 9 C
02 24 24 24 24 n
03 9 67 11 9 C
04 0 0 0 96 T
05 0 0 0 96 T
06 9 9 9 69 T
Binding TFs: 6wc5_N (Homeobox domain)
Binding Sites: 6wc5_G
Publications: Lei X, Zhao J, Sagendorf JM, Rajashekar N, Xu J, Dantas Machado AC, Sen C, Rohs R, Feng P, Chen L. Crystal Structures of Ternary Complexes of MEF2 and NKX2-5 Bound to DNA Reveal a Disease Related Protein-Protein Interaction Interface. J Mol Biol 432:5499-5508 (2020). [Pubmed]

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