DNA Binding Motif

						

			
Accessions: 3d1n_MO (3D-footprint 20231221)

			
Names: POU domain, class 6, transcription factor 1
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Structure of human Brn-5 transcription factor in complex with corticotrophin-releasing hormone gene promoter
Length: 22
Consensus: ATAAAnTATAnnTATAnTTTAT
Weblogo: 
PSSM: P0      A      C      G      T
01     88      2      2      4      A
02      0      0      0     96      T
03     90      2      2      2      A
04     93      1      0      2      A
05     93      0      3      0      A
06     24     24     24     24      n
07     10      2      2     82      T
08     96      0      0      0      A
09      0      2      0     94      T
10     88      4      2      2      A
11     24     24     24     24      n
12     24     24     24     24      n
13     12      8      2     74      T
14     94      0      2      0      A
15      0      0      0     96      T
16     80      4      2     10      A
17     24     24     24     24      n
18      0      0      0     96      T
19      0      0      0     96      T
20      2      1      0     93      T
21     88      2      4      2      A
22      2      2      4     88      T
Binding TFs: 3d1n_M / 3d1n_O (Homeobox domain, Pou domain - N-terminal to homeobox domain)
Binding Sites: 3d1n_G
3d1n_H
			
Publications: Pereira J.H, Kim S.H. Structure of human Brn-5 transcription factor in complex with CRH gene promoter. Journal of structural biology 167:159-65 (2009). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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