DNA Binding Motif

Accessions: 1mdm_AB (3D-footprint 20231221)
Names: PAIRED BOX PROTEIN PAX-5
Organisms: Homo sapiens, Mus musculus
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: INHIBITED FRAGMENT OF ETS-1 AND PAIRED DOMAIN OF PAX5 BOUND TO DNA
Length: 19
Consensus: CCAnGnnnnCnnnTCTCCG
Weblogo:
PSSM: P0 A C G T
01 1 90 0 5 C
02 11 67 13 5 C
03 84 5 0 7 A
04 24 24 24 24 n
05 5 11 73 7 G
06 24 24 24 24 n
07 24 24 24 24 n
08 24 24 24 24 n
09 24 24 24 24 n
10 5 81 5 5 C
11 24 24 24 24 n
12 24 24 24 24 n
13 24 24 24 24 n
14 5 5 5 81 T
15 0 96 0 0 C
16 0 0 0 96 T
17 0 96 0 0 C
18 0 96 0 0 C
19 0 0 96 0 G
Type: Heterodimer
Binding TFs: 1mdm_A ('Paired box' domain)
1mdm_B (Ets-domain)
Binding Sites: 1mdm_C
1mdm_D
Publications: Garvie C.W, Pufall M.A, Graves B.J, Wolberger C. Structural analysis of the autoinhibition of Ets-1 and its role in protein partnerships. The Journal of biological chemistry 277:45529-36 (2002). [Pubmed]

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