DNA Binding Motif

						

			
Accessions: TCF4_DBD (HumanTF 1.0), MA0830.1 (JASPAR 2024)

			
Names: TCF4
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: dimeric; SELEX cycle: 2, HT-SELEX
Length: 10
Consensus: yrCACCTGbw
Weblogo: 
PSSM: P0      A      C      G      T
01   4738   8284   2128   5185      y
02   7822   2465   9640    409      r
03      6  20335      0     13      C
04  20335      0      0      0      A
05      0  20335   2315   1334      C
06     56  20335    387      0      C
07    117      0      0  20335      T
08     27      5  20335     25      G
09    374   7336   6324   6301      b
10   5305   4812   4838   5380      w
Type: Heterodimer
Binding TFs: P15884 (Helix-loop-helix DNA-binding domain)
TCF4_DBD (Helix-loop-helix DNA-binding domain)
P15884
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Kophengnavong T, Michnowicz J.E, Blackwell T.K. Establishment of distinct MyoD, E2A, and twist DNA binding specificities by different basic region-DNA conformations. Molecular and cellular biology 20:261-72 (2000). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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