DNA Binding Motif

						

			
Accessions: FIGLA_DBD (HumanTF 1.0), MA0820.1 (JASPAR 2024)

			
Names: FIGLA
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: dimeric; SELEX cycle: 4, HT-SELEX
Length: 10
Consensus: wmCACCTGkw
Weblogo: 
PSSM: P0      A      C      G      T
01    886    270    175    449      w
02    690    693    160    237      m
03      0   1780      0     29      C
04   1780     46      0     14      A
05      0   1780    527      0      C
06      9   1780    311      0      C
07     56      0     17   1780      T
08     36     33   1780     65      G
09    154    225    569    832      k
10    455    283    289    753      w
Type: Heterodimer
Binding TFs: FIGLA_DBD (Helix-loop-helix DNA-binding domain)
Q6QHK4 (Helix-loop-helix DNA-binding domain)
Q6QHK4
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Zhao H, Chen ZJ, Qin Y, Shi Y, Wang S, Choi Y, Simpson JL, Rajkovic A. Transcription factor FIGLA is mutated in patients with premature ovarian failure. Am J Hum Genet 82:1342-8 (2008). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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