DNA Binding Motif

						

			
Accessions: UP00617D_1 (UniPROBE 20160601)

			
Names: Brain-3C, Brain-specific homeobox/POU domain protein 3C, Brn-3C, BRN3C, class 4, DFNA15, MGC138412, POU domain, POU4F3_N316K_R1, transcription factor 3
Organisms: Homo sapiens
Libraries: UniPROBE 20160601 1
1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed]
Length: 22
Consensus: thravkTTATTAATAwtktmak
Weblogo: 
PSSM: P0      A      C      G      T
01   0.10   0.18   0.08   0.64      t
02   0.26   0.27   0.20   0.27      h
03   0.28   0.23   0.31   0.19      r
04   0.59   0.16   0.09   0.16      a
05   0.28   0.29   0.33   0.10      v
06   0.14   0.16   0.29   0.40      k
07   0.17   0.04   0.09   0.70      T
08   0.02   0.08   0.01   0.89      T
09   0.97      0   0.01   0.02      A
10   0.04      0      0   0.96      T
11   0.04      0   0.02   0.94      T
12   0.94   0.02      0   0.04      A
13   0.96      0      0   0.04      A
14   0.02   0.01      0   0.97      T
15   0.89   0.01   0.08   0.02      A
16   0.57   0.08   0.04   0.31      w
17   0.20   0.18   0.19   0.43      t
18   0.10   0.22   0.27   0.41      k
19   0.24   0.08   0.07   0.60      t
20   0.32   0.29   0.19   0.20      m
21   0.54   0.12   0.10   0.24      a
22   0.17   0.21   0.30   0.32      k
Binding TFs: UP00617D (Homeobox domain, Pou domain - N-terminal to homeobox domain)
Binding Sites: AAATTAAT
AATTAATA
AATTAATG
AATTAATT
ATATTAAT
ATTAATAA
ATTAATAC
ATTAATAG
ATTAATGA
ATTAATTA
CATTAATA
CATTAATG
CTCATTAA
TATTAATA
TCATTAAA
TTAATTAA
AATATTTA
ACATTAAT
ATTAATGC
ATTAATGG
			
Publications: Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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