DNA Binding Motif

Accessions: 5mhj_A (3D-footprint 20231221)
Names: Major viral transcription factor ICP4
Organisms: Human herpes simplex virus 1, Human herpesvirus 1 (strain 17) (HHV-1)
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: ICP4 DNA-binding domain, lacking intrinsically disordered region, in complex with 12mer DNA duplex from its own promoter
Length: 4
Consensus: aCGa
01 57 13 13 13 a
02 0 96 0 0 C
03 0 0 96 0 G
04 54 13 13 16 a
Binding TFs: 5mhj_A (Herpesvirus ICP4-like protein N-terminal region)
Binding Sites: 5mhj_E
Publications: Tunnicliffe RB, Lockhart-Cairns MP, Levy C, Mould AP, Jowitt TA, Sito H, Baldock C, Sandri-Goldin RM, Golovanov AP. The herpes viral transcription factor ICP4 forms a novel DNA recognition complex. Nucleic Acids Res 45:8064-8078 (2017). [Pubmed]

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