DNA Binding Motif

Accessions: UP00186A_1 (UniPROBE 20160601)
Names: C530044H18Rik, Evi8, Homeobox protein Meis1, Meis1, myeloid ecotropic viral integration site 1
Organisms: Mus musculus
Libraries: UniPROBE 20160601 1
1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed]
Length: 16
Consensus: wasbAsCTGTCAWwac
Weblogo:
PSSM: P0 A C G T
01 0.43 0.11 0.13 0.32 w
02 0.51 0.06 0.21 0.22 a
03 0.23 0.28 0.28 0.22 s
04 0.09 0.29 0.36 0.26 b
05 0.95 0.01 0.03 0.02 A
06 0.03 0.44 0.51 0.03 s
07 0.02 0.96 0.01 0 C
08 0 0.02 0 0.98 T
09 0.01 0 0.99 0 G
10 0.03 0 0 0.97 T
11 0 0.99 0 0 C
12 0.99 0 0 0 A
13 0.70 0.02 0.01 0.27 W
14 0.36 0.09 0.09 0.46 w
15 0.45 0.20 0.18 0.16 a
16 0.20 0.39 0.17 0.23 c
Binding TFs: UP00186A (Homeobox domain, Homeobox KN domain)
Binding Sites: AACTGTCA
AATGACAG
ACATGTCA
ACCTGTCA
AGCTGTCA
ATCTGTCA
ATGACAGC
ATGACAGG
ATTGACAG
CCTGTCAA
CCTGTCAC
CTGACAGC
CTGTCAAA
CTGTCAAC
GCCTGTCA
GCTGTCAA
GCTGTCAC
GGCTGTCA
TCCTGTCA
TGACAGCA
Publications: Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed]

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