DNA Binding Motif

						

			
Accessions: NFATC4_3 (HT-SELEX2 May2017), MA1525.1 (JASPAR 2024)

			
Names: NFATC4
Organisms: Homo sapiens
Libraries: HT-SELEX2 May2017 1, JASPAR 2024 2
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: HT-SELEX
Length: 10
Consensus: aryGGAAAmw
Weblogo: 
PSSM: P0      A      C      G      T
01   1652    916    963    819      a
02   4349    329   2369    843      r
03     95   1534      0   2816      y
04      0      0   4349      0      G
05      0      0   4349      0      G
06   4349     39      0      0      A
07   4349      0      0      0      A
08   4349   1084    127    259      A
09   4349   3276   1789   1292      m
10   1132    632    348   2239      w
Type: Heterodimer
Binding TFs: Q14934 (Rel homology domain (RHD), IPT/TIG domain)
NFATC4 (Rel homology domain (RHD), IPT/TIG domain)
Q14934
			
Publications: Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]


Badran B. M., Wolinsky S. M., Burny A., Willard-Gallo K. E. Identification of three NFAT binding motifs in the 5'-upstream region of the human CD3gamma gene that differentially bind NFATc1, NFATc2, and NF-kappa B p50.. J. Biol. Chem. 277:47136-48 (2002). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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