DNA Binding Motif

						

			
Accessions: HOXB2_PAX1_1 (HumanTF2 1.0), UN0561.1 (JASPAR 2024)

			
Names: HOXB2_PAX1, HOXB2::PAX1
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 17
Consensus: ysGTCACGChyCATTdm
Weblogo: 
PSSM: P0      A      C      G      T
01    531   1590    808   1147      y
02    326   2358   1182    210      s
03      8      6   4076     45      G
04    150     41      0   4076      T
05     11   4076     11    117      C
06   4076     23      0      0      A
07     14   4076      6    303      C
08      0      0   4076      0      G
09     17   3306    764      0      C
10   1072   1152    180   1671      h
11     39   1948      0   4076      y
12     46   4076    411      1      C
13   4076      1    897      0      A
14    119    604    250   4076      T
15      3    122      0   4076      T
16   1621      9   1169   1277      d
17   1811   1438    824      2      m
Type: Heterodimer
Binding TFs: HOXB2_TF1 (Homeobox domain)
PAX1_TF2 ('Paired box' domain, Homeodomain-like domain)
P15863 ('Paired box' domain, Homeodomain-like domain)
P15863
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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