DNA Binding Motif

						

			
Accessions: NR1D2 (HumanTF2 1.0), MA1532.2 (JASPAR 2024)

			
Names: NR1D2
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: HT-SELEX; HT-SELEX generated reference PWM, HT-SELEX
Length: 15
Consensus: TrGGTyAGTrGGTCA
Weblogo: 
PSSM: P0      A      C      G      T
01    804   1877   5429  57431      T
02  29828    939  30693    256      r
03     66     85  58866   4734      G
04    107     20  60974     37      G
05     28    481   4341  58858      T
06     26  30265     13  30822      y
07  60895      0      2    309      A
08   3894   7626  50343   2922      G
09     67    466    969  60489      T
10  44879    439  40772    127      r
11     63     25  57509  13104      G
12    262     81  61054     69      G
13   1549   2348   5189  57177      T
14     42  56830    924   7273      C
15  56565     44   9354    538      A
Type: Heterodimer
Binding TFs: NR1D2_TF2 (Zinc finger, C4 type (two domains))
Q14995 (Ligand-binding domain of nuclear hormone receptor, Zinc finger, C4 type (two domains))
Q14995 (Ligand-binding domain of nuclear hormone receptor, Zinc finger, C4 type (two domains))
Q14995
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]


Khan SA, Vanden Heuvel JP. Role of nuclear receptors in the regulation of gene expression by dietary fatty acids (review). J Nutr Biochem 14:554-67 (2003). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.