DNA Binding Motif

						

			
Accessions: PAX3 (HumanTF2 1.0)

			
Names: PAX3
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: HT-SELEX; HT-SELEX generated reference PWM, the experiment but not the clone has been previously described in Nitta et al 2015, "Conservation of transcription factor binding specificities across 600 million years of bilateria evolution"
Length: 15
Consensus: GTCACGsywaATTAr
Weblogo: 
PSSM: P0      A      C      G      T
01      2      0   2533     15      G
02     69     12      0   2533      T
03      0   2533     22    252      C
04   2533      6      6      0      A
05      0   2533      5    253      C
06    394     13   2533      0      G
07      4   2533   4904     16      s
08     86    861     10   1576      y
09    640    267    344   1282      w
10   1688    845    516    355      a
11   2533     34    228    460      A
12      4     13      5   2533      T
13     41     68      6   2533      T
14   2533     28     42    262      A
15    851    364    728    590      r
Binding TFs: PAX3_TF1 (Homeobox domain, 'Paired box' domain, Homeobox KN domain)
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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