DNA Binding Motif

						

			
Accessions: 2kek_B (3D-footprint 20231221)

			
Names: Lactose operon repressor
Organisms: Escherichia coli, strain K12
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Solution structure of a dimer of LAC repressor DNA-binding domain complexed to its natural operator O3
Length: 10
Consensus: TnGCnnTGCG
Weblogo: 
PSSM: P0      A      C      G      T
01      7      7      9     73      T
02     24     24     24     24      n
03      7      7     73      9      G
04      7     73      7      9      C
05     24     24     24     24      n
06     24     24     24     24      n
07      9      7      7     73      T
08      0      0     96      0      G
09      0     96      0      0      C
10      0      0     96      0      G
Binding TFs: 2kek_B (Bacterial regulatory proteins, lacI family)
Binding Sites: 2kek_C
2kek_D
			
Publications: Romanuka J, Folkers G.E, Biris N, Tishchenko E, Wienk H, Bonvin A.M, Kaptein R, Boelens R. Specificity and affinity of Lac repressor for the auxiliary operators O2 and O3 are explained by the structures of their protein-DNA complexes. Journal of molecular biology 390:478-89 (2009). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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