DNA Binding Motif

						

			
Accessions: ERF_SREBF2_2 (HumanTF2 1.0), MA1939.1 (JASPAR 2024)

			
Names: ERF_SREBF2, ERF::SREBF2
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 17
Consensus: ssCGGAArTCACGTGAy
Weblogo: 
PSSM: P0      A      C      G      T
01     73     99    122     78      s
02     93    211    162     17      s
03     58    373      1     34      C
04      5      7    373      0      G
05      2     15    373     14      G
06    373      7      0     31      A
07    373     61      0     73      A
08    227      0    146      1      r
09      4      4     13    352      T
10     37    373      7     12      C
11    373      2      4      1      A
12      0    373      5     15      C
13      0     96    373      5      G
14     30     10      8    373      T
15      0      0    373     10      G
16    299      0     24     50      A
17      7    111      8    246      y
Type: Heterodimer
Binding TFs: SREBF2_TF2 (Helix-loop-helix DNA-binding domain)
Q12772 (Helix-loop-helix DNA-binding domain)
ERF_TF1 (Ets-domain)
SREBF2_TF1 (Helix-loop-helix DNA-binding domain)
Q12772
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]


Chatterjee R, Zhao J, He X, Shlyakhtenko A, Mann I, Waterfall JJ, Meltzer P, Sathyanarayana BK, FitzGerald PC, Vinson C. Overlapping ETS and CRE Motifs ((G/C)CGGAAGTGACGTCA) preferentially bound by GABPα and CREB proteins. G3 (Bethesda) 2:1243-56 (2012). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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