DNA Binding Motif

Accessions: UP00128A_1 (UniPROBE 20160601)
Names: 9430075J19Rik, A230098E07Rik, Brain-2, Brain-specific homeobox/POU domain protein 2, Brn-2, Brn2, class 3, Nervous system-specific octamer-binding transcription factor N-Oct-3, Otf7, POU domain, Pou3f2, Protein Brn-2, transcription factor 2
Organisms: Mus musculus
Libraries: UniPROBE 20160601 1
1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed]
Length: 17
Consensus: swtAaTTAATTArkkyr
Weblogo:
PSSM: P0 A C G T
01 0.15 0.26 0.45 0.14 s
02 0.29 0.19 0.23 0.29 w
03 0.23 0.11 0.22 0.44 t
04 0.69 0.07 0.11 0.13 A
05 0.62 0.14 0.10 0.14 a
06 0.07 0.24 0 0.68 T
07 0.01 0.03 0.01 0.95 T
08 0.97 0.01 0 0.01 A
09 0.98 0 0 0.01 A
10 0.01 0 0 0.98 T
11 0.01 0.01 0.05 0.94 T
12 0.96 0.02 0.01 0.02 A
13 0.36 0.02 0.53 0.09 r
14 0.09 0.16 0.27 0.48 k
15 0.25 0.14 0.28 0.34 k
16 0.24 0.26 0.21 0.30 y
17 0.28 0.15 0.36 0.22 r
Binding TFs: UP00128A (Homeobox domain, Pou domain - N-terminal to homeobox domain)
Binding Sites: AAATTAAT
AATAATTA
AATTAATA
AATTAATT
ACTAATTA
ATAATGAG
ATAATTAA
ATAATTAG
ATTAATTA
CATAATTA
CCTCATTA
CTAATTAA
CTAATTAG
CTCATTAA
CTTAATTA
GCTAATTA
GTTAATTA
TAATTAAA
TAATTAGA
TTAATTAA
Publications: Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed]

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