DNA Binding Motif

						

			
Accessions: RXRA_full_1 (HumanTF 1.0), MA0512.2 (JASPAR 2024)

			
Names: RXRA
Organisms: Homo sapiens, Mus musculus
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: dimeric; SELEX cycle: 3, HT-SELEX
Length: 14
Consensus: grGGTCAAAGGTCA
Weblogo: 
PSSM: P0      A      C      G      T
01  12568   5031  30811   2084      g
02  21345    200  30406     75      r
03    110     77  38290    159      G
04    132     72  36414   4372      G
05     47    109    372  40596      T
06     97  44342    577   2686      C
07  46204     51    120     21      A
08  45275     89    830    368      A
09  45265     73   1369     19      A
10     39     71  39798     51      G
11     63     85  38185   3335      G
12     44    114    267  39867      T
13     63  43686    348   1775      C
14  44403    158   2447     37      A
Type: Heterodimer
Binding TFs: P28700 (Ligand-binding domain of nuclear hormone receptor, Zinc finger, C4 type (two domains), Nuclear/hormone receptor activator site AF-1)
RXRA_full (Ligand-binding domain of nuclear hormone receptor, Zinc finger, C4 type (two domains), Nuclear/hormone receptor activator site AF-1)
P28700
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Zhang X.-K., Lehmann J., Hoffmann B., Dawson M. I., Cameron J., Graupner G., Hermann T., Tran P., Pfahl M. Homodimer formation of retinoid X receptor induced by 9-cis retinoic acid. Nature 358:587-591 (1992). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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