DNA Binding Motif

Accessions: UP00171A_1 (UniPROBE 20160601)
Names: homeo box, Homeobox protein MSX-3, msh-like 3, Msx3
Organisms: Mus musculus
Libraries: UniPROBE 20160601 1
1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed]
Length: 16
Consensus: mamAAcyAATTAAktw
Weblogo:
PSSM: P0 A C G T
01 0.32 0.35 0.23 0.10 m
02 0.60 0.13 0.16 0.10 a
03 0.40 0.29 0.10 0.21 m
04 0.75 0.05 0.13 0.06 A
05 0.77 0.09 0.09 0.05 A
06 0.04 0.67 0.19 0.10 c
07 0 0.52 0 0.47 y
08 0.99 0 0.01 0 A
09 0.99 0.01 0 0 A
10 0.01 0 0 0.99 T
11 0.01 0.01 0 0.98 T
12 0.99 0 0.01 0.01 A
13 0.70 0.03 0.15 0.12 A
14 0.18 0.18 0.30 0.33 k
15 0.22 0.22 0.18 0.37 t
16 0.31 0.21 0.10 0.38 w
Binding TFs: UP00171A (Homeobox domain)
Binding Sites: GGTAATTA
AATAATTA
AATTAATT
ACCAATTA
ACTAATTA
AGCAATTA
AGTAATTA
ATAATTAC
ATAATTAG
ATAATTGG
ATTAATTA
CCAATTAA
CCAATTAG
CTAATTAA
CTAATTAG
GCAATTAA
GCTAATTA
GTTAATTA
TAATTGCA
TTAATTAA
Publications: Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed]

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