DNA Binding Motif

						

			
Accessions: 4l18_AB (3D-footprint 20231221)

			
Names: Runt-related transcription factor 1
Organisms: Mus musculus, Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Crystal structure of Runx1 and Ets1 bound to TCR alpha promoter (crystal form 3)
Length: 12
Consensus: aGGATGTGGCTT
Weblogo: 
PSSM: P0      A      C      G      T
01     64     10     12     10      a
02      0      0     96      0      G
03      0      0     96      0      G
04     96      0      0      0      A
05      0      0      0     96      T
06      0      0     96      0      G
07      0      0      0     96      T
08      0      0     96      0      G
09      0      0     96      0      G
10     10     66     10     10      C
11      0      0     10     86      T
12     10      0      0     86      T
Type: Heterodimer
Binding TFs: 4l18_A (Runt domain)
4l18_B (Ets-domain)
Binding Sites: 4l18_C
4l18_D
			
Publications: Shrivastava T, Mino K, Babayeva N.D, Baranovskaya O.I, Rizzino A, Tahirov T.H. Structural basis of Ets1 activation by Runx1. Leukemia 28:2040-8 (2014). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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