DNA Binding Motif

Accessions: GCM1_NHLH1_2 (HumanTF2 1.0)
Names: GCM1_NHLH1
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX
Length: 20
Consensus: gCAGsTGykgyysrTrmGGG
Weblogo:
PSSM: P0 A C G T
01 17 28 142 56 g
02 14 244 26 0 C
03 244 0 1 10 A
04 12 41 244 0 G
05 24 244 112 33 s
06 11 0 6 244 T
07 0 17 244 0 G
08 51 94 27 71 y
09 17 1 156 70 k
10 33 35 138 38 g
11 48 97 24 75 y
12 37 85 50 71 y
13 3 128 89 23 s
14 124 44 67 9 r
15 47 13 36 244 T
16 76 25 168 0 r
17 156 244 48 67 m
18 72 0 244 29 G
19 0 19 244 6 G
20 1 0 244 1 G
Type: Heterodimer
Binding TFs: GCM1_TF1 (GCM motif protein)
NHLH1_TF2 (Helix-loop-helix DNA-binding domain)
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

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