DNA Binding Motif

						

			
Accessions: 2kei_AB (3D-footprint 20231221)

			
Names: Lactose operon repressor
Organisms: Escherichia coli, strain K12
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Refined Solution Structure of a Dimer of LAC repressor DNA-Binding domain complexed to its natural operator O1
Length: 16
Consensus: TGTTATCCGCTCACAA
Weblogo: 
PSSM: P0      A      C      G      T
01      0      0      0     96      T
02      0      0     96      0      G
03      0      0      0     96      T
04      0      0      0     96      T
05     96      0      0      0      A
06      7      7      9     73      T
07      7     82      0      7      C
08      0     96      0      0      C
09      0      0     96      0      G
10      0     96      0      0      C
11      7      7      9     73      T
12      0     96      0      0      C
13     96      0      0      0      A
14      0     96      0      0      C
15     96      0      0      0      A
16     66      7      9     14      A
Binding TFs: 2kei_A / 2kei_B (Bacterial regulatory proteins, lacI family)
Binding Sites: 2kei_C
2kei_D
			
Publications: Romanuka J, Folkers G.E, Biris N, Tishchenko E, Wienk H, Bonvin A.M, Kaptein R, Boelens R. Specificity and affinity of Lac repressor for the auxiliary operators O2 and O3 are explained by the structures of their protein-DNA complexes. Journal of molecular biology 390:478-89 (2009). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
Disclaimer and license


These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.